Tsc22d3^tm1.2Dpea
Targeted Allele Detail

Summary

• Symbol: Tsc22d3^tm1.2Dpea
• Name: TSC22 domain family, member 3; targeted mutation 1.2, David Pearce
• MGI ID: MGI:6294279
• Synonyms: Gilz^-
• Gene: Tsc22d3 Location: ChrX:139440277-139501257 bp, - strand Genetic Position: ChrX, 61.35 cM, cytoband F1
• Alliance: Tsc22d3^tm1.2Dpea page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:273574
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129Sv/Pas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting vector consists an Frt-flanked neomycin selection cassette followed by one loxP site was inserted 3' to the exon 4 common to all three isoforms of the gene. A second loxP site was inserted 5' to exon 3 common to all three isoforms. Common exon 3 and 4 are reffered as exon 5-6 in J:223992 for similar construct used to create an allele Tsc22d3. The loxP flanked sequences, including exons 3-4 and the Frt-flanked neomycin selection cassette, were removed via Cre-mediated recombination. (J:273574)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tsc22d3 Mutation: 3 strains or lines available

References

• Original: J:273574 Rashmi P, et al., Glucocorticoid-induced leucine zipper protein regulates sodium and potassium balance in the distal nephron. Kidney Int. 2017 May;91(5):1159-1177
• All: 1 reference(s)