Rr95^tm2.1Itan
Targeted Allele Detail

Summary

• Symbol: Rr95^tm2.1Itan
• Name: regulatory region 95; targeted mutation 2.1, Ichiro Taniuchi
• MGI ID: MGI:6294096
• Synonyms: Cd4^deltaE4M, Cd4^tm2.1Itan
• Gene: Rr95 Location: Chr6:124862196-124862560 bp Genetic Position: Chr6, Syntenic
• Alliance: Rr95^tm2.1Itan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:267930
• Parent Cell Line: M1/M-1 (ES Cell)
• Strain of Origin: (129 x C57BL/6)F1

Mutation description

• Allele Type: Targeted (Modified regulatory region)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Homologous recombination with a targeting vector removed 365 bp containing Cd4 maturation enhancer E4m in Cd4 intron 1 and inserted a loxP site flanked neomycin resistance gene cassette upstream of neighboring Cd4 silencer S4 (Rr96). The neo cassette was removed through subsequent cre-mediated recombination. (J:267930)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr95 Mutation: 0 strains or lines available

References

• Original: J:267930 Kojo S, et al., Runx-dependent and silencer-independent repression of a maturation enhancer in the Cd4 gene. Nat Commun. 2018 Sep 5;9(1):3593
• All: 1 reference(s)