Ar^tm1.1Ohl
Targeted Allele Detail

Summary

• Symbol: Ar^tm1.1Ohl
• Name: androgen receptor; targeted mutation 1.1, Claes Ohlsson
• MGI ID: MGI:6287672
• Synonyms: AR^SUM-
• Gene: Ar Location: ChrX:97192375-97366821 bp, + strand Genetic Position: ChrX, 42.82 cM
• Alliance: Ar^tm1.1Ohl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:273238
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: Two conserved lysine residues in exon 1 were replaced by arginine residues at amino acid 381 and 500 (K381R and K500R). A neomycin selection cassette was removed. These two mutations abolish SUMOylation at the two lysines. (J:273238)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ar Mutation: 23 strains or lines available

References

• Original: J:273238 Wu J, et al., Androgen receptor SUMOylation regulates bone mass in male mice. Mol Cell Endocrinol. 2019 Jan 5;479:117-122
• All: 1 reference(s)