Igs2^{tm1(cas9*)Ndva}
Targeted Allele Detail

Summary

• Symbol: Igs2^{tm1(cas9*)Ndva}
• Name: intergenic site 2; targeted mutation 1, Nadav Ahituv
• MGI ID: MGI:6287265
• Synonyms: H11P3^{CAG-dCas9-VP64}
• Gene: Igs2 Location: unknown Genetic Position: Chr11, Syntenic
• Alliance: Igs2^{tm1(cas9*)Ndva} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:272371
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The targeting construct inserted the mammalian codon-optimized Streptococcus pyogenes dCas9 with a VP64 domain. (J:272371)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igs2 Mutation: 68 strains or lines available

References

• Original: J:272371 Matharu N, et al., CRISPR-mediated activation of a promoter or enhancer rescues obesity caused by haploinsufficiency. Science. 2019 Jan 18;363(6424)
• All: 2 reference(s)