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Pappam1Btlr
Chemically induced Allele Detail
Nomenclature
Symbol: Pappam1Btlr
Name: pregnancy-associated plasma protein A; mutation 1, Bruce Beutler
MGI ID: MGI:6286271
Synonyms: caer
Gene: Pappa  Location: Chr4:65124174-65357509 bp, + strand  Genetic Position: Chr4, 34.14 cM
Mutation
origin
Strain of Origin:  C57BL/6J
Project Collection: Beutler Mutagenetix
Mutation
description
Allele Type:    Chemically induced (ENU) (Not Specified)
Mutation:    Single point mutation
 
Mutation detailsENU-induced C to A transversion at base pair 65,124,891 (v38) on chromosome 4, or base pair 718 in the GenBank genomic region NC_000070. The mutation corresponds to residue 718 in the mRNA sequence NM_021362 within exon 1 of 22 total exons. The mutation results in a threonine to lysine substitution at position 117 (T117K) in the PAPP-A protein. (J:272859)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pappa Mutation:  3 strains or lines available
Notes
https://mutagenetix.utsouthwestern.edu/phenotypic/phenotypic_rec.cfm?pk=3577
References
Original:  J:272859 Zhang Z, et al., Mutagenetix entry for caer. MGI Direct Data Submission. 2019;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory