Pcdhg^em31Rwb
Endonuclease-mediated Allele Detail

Summary

• Symbol: Pcdhg^em31Rwb
• Name: protocadherin gamma cluster; endonuclease-mediated mutation 31, Robert W Burgess
• MGI ID: MGI:6285824
• Gene: Pcdhg Location: unknown Genetic Position: Chr18, Syntenic

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Modified isoform(s))
• Mutation: Intragenic deletion
• Mutation details: This allele was generated through shotgun CRISPR/Cas9 editing using pooled sgRNAs that targeted each variable exon of the Pcdhg cluster and this allele was found to have frameshift or other mutations disrupting the variable exons A4, A12, and C5, and in-frame mutations in C3 and C4. (J:285314)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pcdhg Mutation: 13 strains or lines available

References

• Original: J:285314 Garrett AM, et al., CRISPR/Cas9 interrogation of the mouse Pcdhg gene cluster reveals a crucial isoform-specific role for Pcdhgc4. PLoS Genet. 2019 Dec;15(12):e1008554
• All: 1 reference(s)