Pcdhgem17Rwb
Endonuclease-mediated Allele Detail
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Symbol: |
Pcdhgem17Rwb |
Name: |
protocadherin gamma cluster; endonuclease-mediated mutation 17, Robert W Burgess |
MGI ID: |
MGI:6285805 |
Gene: |
Pcdhg Location: unknown Genetic Position: Chr18, Syntenic
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Allele Type: |
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Endonuclease-mediated (Modified isoform(s)) |
Mutation: |
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Intragenic deletion
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Mutation details: This allele was generated through shotgun CRISPR/Cas9 editing using pooled sgRNAs that targeted each variable exon of the Pcdhg cluster and this allele includes frame shifting mutations in exons A12 and C3, an in-frame mutation in exon B6, and a structural rearrangement between exons A1 and A5
(J:285314)
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Inheritance: |
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Not Specified |
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Pcdhg Mutation: |
12 strains or lines available
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Original: |
J:285314 Garrett AM, et al., CRISPR/Cas9 interrogation of the mouse Pcdhg gene cluster reveals a crucial isoform-specific role for Pcdhgc4. PLoS Genet. 2019 Dec;15(12):e1008554 |
All: |
1 reference(s) |
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