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Glb1em2Lutzy
Endonuclease-mediated Allele Detail
Nomenclature
Symbol: Glb1em2Lutzy
Name: galactosidase, beta 1; endonuclease-mediated mutation 2, Cathy Lutz
MGI ID: MGI:6285745
Synonyms: Glb1 Y155Y L156R
Gene: Glb1  Location: Chr9:114230146-114303447 bp, + strand  Genetic Position: Chr9, 64.4 cM
Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Endonuclease-mediated (Humanized sequence)
Mutation:    Nucleotide substitutions
 
Mutation detailsCRISPR/Cas9 endonuclease mediated genome editing is used to introduce the the Y155Y and L156R point mutations. Murine L156R is a missense mutation corresponding to the clinical L155R mutation associated with GM1-gangliosidosis and Mucopolysaccharidosis type IVB (Morquio). (J:94077)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Glb1 Mutation:  41 strains or lines available
References
Original:  J:94077 Mutant Mouse Regional Resource Centers, Information obtained from the Mutant Mouse Regional Resource Centers (MMRRC). Unpublished. 2004-2015;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory