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Tlk2tm1.2Strc
Targeted Allele Detail
Nomenclature
Symbol: Tlk2tm1.2Strc
Name: tousled-like kinase 2 (Arabidopsis); targeted mutation 1.2, Travis H Stracker
MGI ID: MGI:6274362
Synonyms: Tlk2-
Gene: Tlk2  Location: Chr11:105178807-105283959 bp, + strand  Genetic Position: Chr11, 68.61 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:268910
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA construct, containing an FRT flanked cassette, encoding a splice-acceptor site, lacZ gene and neo resistance gene, and a loxP site, was inserted in intron 3 and a second loxP site was inserted in intron 4 via homologous recombination. Recombinase mediated recombination removed the FRT flanked cassette and exon 4. (J:268910)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tlk2 Mutation:  43 strains or lines available
References
Original:  J:268910 Segura-Bayona S, et al., Differential requirements for Tousled-like kinases 1 and 2 in mammalian development. Cell Death Differ. 2017 Nov;24(11):1872-1885
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory