Mlip^tm1.1Burg
Targeted Allele Detail

Summary

• Symbol: Mlip^tm1.1Burg
• Name: muscular LMNA-interacting protein; targeted mutation 1.1, Patrick G Burgon
• MGI ID: MGI:6273621
• Synonyms: Mlip^deltaE1
• Gene: Mlip Location: Chr9:77009366-77260062 bp, - strand Genetic Position: Chr9, 42.67 cM, cytoband E1
• Alliance: Mlip^tm1.1Burg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:243471
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 1 and a PGK-neo cassette and loxP site were inserted downstream of exon 1 via homologous recombination. Cre mediated recombination removed exon 1 and the neo cassette. An alternative transcript expressed from exon 1b is detected in the brains, but not the hearts, of homozygous mice. (J:243471, J:268937)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mlip Mutation: 28 strains or lines available

References

• Original: J:243471 Cattin ME, et al., Deletion of MLIP (muscle-enriched A-type lamin-interacting protein) leads to cardiac hyperactivation of Akt/mammalian target of rapamycin (mTOR) and impaired cardiac adaptation. J Biol Chem. 2015 Oct 30;290(44):26699-714
• All: 2 reference(s)