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Transgene Detail
Symbol: Tg(KRT5-Terf2)POBlas
Name: transgene insertion PO, Maria A Blasco
MGI ID: MGI:6258222
Synonyms: PO K5-Terf2
Transgene: Tg(KRT5-Terf2)POBlas  Location: unknown  
Strain of Origin:  (C57BL/6 x CBA)F1
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Tg(KRT5-Terf2)POBlas expresses 1 gene
Mutation detailsThe full-length mouse Terf2 cDNA was placed under control of the 5' regulatory region of the bovine keratin K5 promoter, which targets TERF2 to basal cells and stem cells of the epidermis. Three transgenic lines were generated and analyzed (PM, PN and PO). In the PO line (males and females), the levels of Terf2 mRNA expression in tail and back skin were ~23 times greater than those in wild-type controls. Western blot analysis revealed significantly elevated TERF2 protein levels in primary keratinocytes derived from PO transgenic mice. Combined immunofluorescence and telomeric Q-FISH analysis showed that the overexpressed TERF2 protein localized to telomeres. (J:102653)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 4 anatomical structures
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:102653 Munoz P, et al., XPF nuclease-dependent telomere loss and increased DNA damage in mice overexpressing TRF2 result in premature aging and cancer. Nat Genet. 2005 Oct;37(10):1063-71
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.21
The Jackson Laboratory