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Washc5tm1.2Cbee
Targeted Allele Detail
Nomenclature
Symbol: Washc5tm1.2Cbee
Name: WASH complex subunit 5; targeted mutation 1.2, Christian Beetz
MGI ID: MGI:6256428
Synonyms: E430025E21Rikko
Gene: Washc5  Location: Chr15:59203846-59246016 bp, - strand  Genetic Position: Chr15, 25.17 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:266630
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted 216 bp downstream of exon 12 and a PGK promoter-driven neomycin resistance cassette flanked by frt-sites and preceded by another loxP site were inserted 265 bp upstream of exon 12. The selection cassette was removed via Flp-mediated recombination. Cre-mediated recombination removed exon 12. (J:266630)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Washc5 Mutation:  34 strains or lines available
References
Original:  J:266630 Jahic A, et al., The spectrum of KIAA0196 variants, and characterization of a murine knockout: implications for the mutational mechanism in hereditary spastic paraplegia type SPG8. Orphanet J Rare Dis. 2015 Nov 16;10:147
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/03/2022
MGI 6.21
The Jackson Laboratory