Col1a1^{tm2(tetO-FLT1*)Hsc}
Targeted Allele Detail

Summary

• Symbol: Col1a1^{tm2(tetO-FLT1*)Hsc}
• Name: collagen, type I, alpha 1; targeted mutation 2, Hubert Schorle
• MGI ID: MGI:6202353
• Gene: Col1a1 Location: Chr11:94827050-94843868 bp, + strand Genetic Position: Chr11, 59.01 cM, cytoband D
• Alliance: Col1a1^{tm2(tetO-FLT1*)Hsc} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:315838
• Parent Cell Line: KH2 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Mutation details: RMCE on KH2 cells inserted a cassette that contains a tetracycline responsive element (TRE or tetO) and a soluble form of human Flt1. (J:315838)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Col1a1 Mutation: 166 strains or lines available

Notes

The allele was made in KH2 cells that carry Gt(ROSA)26Sor^{tm1(rtTA*M2)Jae} and Col1a1^{tm13(neo/hygro*)Jae}. This allele was generated with Col1a1^{tm13(neo/hygro*)Jae}.

References

• Original: J:315838 Vogtmann R, et al., Human sFLT1 Leads to Severe Changes in Placental Differentiation and Vascularization in a Transgenic hsFLT1/rtTA FGR Mouse Model. Front Endocrinol (Lausanne). 2019;10:165
• All: 2 reference(s)