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Targeted Allele Detail
Symbol: Nr3c1tm1.1Himo
Name: nuclear receptor subfamily 3, group C, member 1; targeted mutation 1.1, Hisashi Mori
MGI ID: MGI:6201713
Synonyms: Nr3c1loxP
Gene: Nr3c1  Location: Chr18:39543598-39652474 bp, - strand  Genetic Position: Chr18, 21.09 cM
Alliance: Nr3c1tm1.1Himo page
Germline Transmission:  Earliest citation of germline transmission: J:264153
Parent Cell Line:  RENKA (ES Cell)
Strain of Origin:  C57BL/6N
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsTwo loxP sites were inserted into mouse Nr3c1 gene to flank exon 3, follwed by a pgk-Neo cassette flanked by two FRT sites by homologous recombination in ES cells. The chimeric mouse obtained was crossed with a CAG-FLPe mouse to delete the pgk-neo cassette and establish the mouse line. (J:264153)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nr3c1 Mutation:  28 strains or lines available
Original:  J:264153 Inoue R, et al., Glucocorticoid receptor-mediated amygdalar metaplasticity underlies adaptive modulation of fear memory by stress. Elife. 2018 Jun 26;7:e34135
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory