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Transgene Detail
Symbol: Tg(Chrna5-cre)1Et
Name: transgene insertion 1, Eric E Turner
MGI ID: MGI:6201568
Transgene: Tg(Chrna5-cre)1Et  Location: unknown  
Strain of Origin:  Not Specified
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
Mutation detailsA cre-expression cassette, followed by a polyadenylation sequence, was inserted into BAC clone RP24-318N16 at the initiating ATG codon of the first coding exon of the Chrna5 gene so that cre expression is driven by the regulatory sequences of the BAC gene. This BAC clone generated by the Gene Expression Nervous System Atlas (GENSAT) Project was furtehr subcloned to include only Chrna5 and deleting Chrna3 and Chrna4 genes on opposit strand of the original BAC clone. The resulting BAC was used to generate three independent lines. Transgenic line 1 was used for expression analyses. (J:264332)
 Tissue activity of this recombinase allele
Driver: Chrna5     Summary of all recombinase alleles driven by Chrna5. Comparative matrix view of recombinase activities

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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:264332 Morton G, et al., Chrna5-expressing neurons in the interpeduncular nucleus mediate aversion primed by prior stimulation or nicotine exposure. J Neurosci. 2018 Jun 28;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
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