Cybb^tm1.1Geno
Targeted Allele Detail

Summary

• Symbol: Cybb^tm1.1Geno
• Name: cytochrome b-245, beta polypeptide; targeted mutation 1.1, Genoway
• MGI ID: MGI:6201449
• Synonyms: Nox2^fl, Nox2^floxed
• Gene: Cybb Location: ChrX:9301493-9354005 bp, - strand Genetic Position: ChrX, 4.3 cM
• Alliance: Cybb^tm1.1Geno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:265378
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A 3 kb fragment, including the transcriptional initiation site and the first two 2 exons were flanked by loxP sites. A FRT-flanked neomycin selection cassette was inserted after the first loxP site and was removed via Flp-mediated recombination. (J:265378)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cybb Mutation: 47 strains or lines available

References

• Original: J:265378 Sag CM, et al., Distinct Regulatory Effects of Myeloid Cell and Endothelial Cell NAPDH Oxidase 2 on Blood Pressure. Circulation. 2017 May 30;135(22):2163-2177
• All: 8 reference(s)