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Cebpbtm1.1Elgaz
Targeted Allele Detail
Nomenclature
Symbol: Cebpbtm1.1Elgaz
Name: CCAAT/enhancer binding protein (C/EBP), beta; targeted mutation 1.1, Mohamed Elgazzar
MGI ID: MGI:6195224
Synonyms: Cebpbflox
Gene: Cebpb  Location: Chr2:167688915-167690418 bp, + strand  Genetic Position: Chr2, 87.58 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:247885
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  BALB/cJ
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsThe targeting vector contains a loxP site flanked PGK-Neo selection cassette inserted 228 bp downstream of the Cebpb polyadenylation site, and another loxP site inserted 227 bp upstream of the Cebpb initiation start site. Cre-mediated recombination removed the floxed neo cassette. (J:247885)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cebpb Mutation:  10 strains or lines available
Notes
ES cell line = PRX-BALB/cJ 9
References
Original:  J:247885 McPeak MB, et al., Frontline Science: Myeloid cell-specific deletion of Cebpb decreases sepsis-induced immunosuppression in mice. J Leukoc Biol. 2017 Aug;102(2):191-200
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/31/2020
MGI 6.15
The Jackson Laboratory