About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cebpbtm1.1Elgaz
targeted mutation 1.1, Mohamed Elgazzar
MGI:6195224
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Cebpbtm1.1Elgaz/Cebpbtm1.1Elgaz
Lyz2em1.1(cre)Elgaz/Lyz2+ 		BALB/cJ-Cebpbtm1.1Elgaz Lyz2em1.1Elgaz/Elgaz MGI:6195657


Genotype
MGI:6195657
cn1
Allelic
Composition		 Cebpbtm1.1Elgaz/Cebpbtm1.1Elgaz
Lyz2em1.1(cre)Elgaz/Lyz2+
Genetic
Background		 BALB/cJ-Cebpbtm1.1Elgaz Lyz2em1.1Elgaz/Elgaz
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cebpbtm1.1Elgaz mutation (1 available); any Cebpb mutation (23 available)
Lyz2em1.1(cre)Elgaz mutation (0 available); any Lyz2 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal myeloid cell number ( J:247885 )
• monocytic myeloid-derived suppressor cell and polymorphonuclear myeloid-derived suppressor cell numbers do not increase during CLP-induced sepsis

homeostasis/metabolism
decreased circulating interleukin-10 level ( J:247885 )
• CLP-induced early sepsis results in decreased levels of IL10 and TGFB as compared to control
increased circulating interleukin-6 level ( J:247885 )
• CLP-induced early sepsis results in increased levels of TNFA and IL6 as compared to control
increased circulating tumor necrosis factor level ( J:247885 )
• CLP-induced early sepsis results in increased levels of TNFA and IL6 as compared to control
decreased transforming growth factor beta level ( J:247885 )
• CLP-induced early sepsis results in decreased levels of IL10 and TGFB as compared to control

immune system
decreased circulating interleukin-10 level ( J:247885 )
• CLP-induced early sepsis results in decreased levels of IL10 and TGFB as compared to control
increased circulating interleukin-6 level ( J:247885 )
• CLP-induced early sepsis results in increased levels of TNFA and IL6 as compared to control
increased circulating tumor necrosis factor level ( J:247885 )
• CLP-induced early sepsis results in increased levels of TNFA and IL6 as compared to control
decreased susceptibility to bacterial infection ( J:247885 )
• peritoneal bacteria counts are decreased following induction of peritonitis as compared to wild-type
decreased susceptibility to bacterial infection induced morbidity/mortality ( J:247885 )
• induction of peritonitis by cecal ligation and puncture (CLP), results in 80% increased survival by late sepsis

mortality/aging
decreased susceptibility to bacterial infection induced morbidity/mortality ( J:247885 )
• induction of peritonitis by cecal ligation and puncture (CLP), results in 80% increased survival by late sepsis




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory