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Lrrtm3tm1Msa
Targeted Allele Detail
Nomenclature
Symbol: Lrrtm3tm1Msa
Name: leucine rich repeat transmembrane neuronal 3; targeted mutation 1, Matti S Airaksinen
MGI ID: MGI:6191636
Gene: Lrrtm3  Location: Chr10:63928497-64090255 bp, - strand  Genetic Position: Chr10, 32.57 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:262456
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 1 and exon 2 were replaecd with an IRES-tauGFP-LNL cassette. Western blot analysis on crude brain extracts showed that no detectable encoded protein was present in homozygous mice. (J:262456)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lrrtm3 Mutation:  16 strains or lines available
References
Original:  J:262456 Laakso T, et al., LRRTM3 is dispensable for amyloid-beta production in mice. J Alzheimers Dis. 2012;31(4):759-64
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory