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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lrrtm3tm1Msa
targeted mutation 1, Matti S Airaksinen
MGI:6191636
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Lrrtm3tm1Msa/Lrrtm3tm1Msa B6JHsd.129-Lrrtm3tm1Msa MGI:6197027
hm2
 		Lrrtm3tm1Msa/Lrrtm3tm1Msa involves: 129S1/Sv * 129X1/SvJ MGI:6197065
cx3
 		Lrrtm3tm1Msa/Lrrtm3tm1Msa
Tg(APPswe,PSEN1dE9)85Dbo/0 		involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6JHsd MGI:6197029


Genotype
MGI:6197027
hm1
Allelic
Composition		 Lrrtm3tm1Msa/Lrrtm3tm1Msa
Genetic
Background		 B6JHsd.129-Lrrtm3tm1Msa
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrrtm3tm1Msa mutation (0 available); any Lrrtm3 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:262456 )
• mice are viable and exhibit no obvious physical abnormalities




Genotype
MGI:6197065
hm2
Allelic
Composition		 Lrrtm3tm1Msa/Lrrtm3tm1Msa
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrrtm3tm1Msa mutation (0 available); any Lrrtm3 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
decreased dendritic spine density ( J:263400 )
• in dentate gyrus granule neurons
• modestly reduced of the number of dendritic spines of asymmetric/excitatory synapses in middle molecular layer at P14
• however, excitatory synapse density is normal in CA1 pyramidal neurons and the number of GABA+ presynaptic boutons is normal
abnormal action potential ( J:263400 )
• lower firing rate of dentate granule neurons
• however, CA1 pyramidal neurons exhibit normal firing rates
abnormal CNS synaptic transmission ( J:263400 )
• small decrease in evoked excitatory synaptic transmission
• however, maximal response is normal
decreased excitatory postsynaptic current amplitude ( J:263400 )
• in dentate gyrus granule cells
abnormal miniature excitatory postsynaptic currents ( J:263400 )
• reduced amplitude with increased frequency in dentate gyrus granule cells
• however, miniature miniature inhibitory postsynaptic current frequency and amplitude are normal
abnormal synaptic depression ( J:263400 )
• faster depression of evoked EPSC amplitude




Genotype
MGI:6197029
cx3
Allelic
Composition		 Lrrtm3tm1Msa/Lrrtm3tm1Msa
Tg(APPswe,PSEN1dE9)85Dbo/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6JHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrrtm3tm1Msa mutation (0 available); any Lrrtm3 mutation (31 available)
Tg(APPswe,PSEN1dE9)85Dbo mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
homeostasis/metabolism phenotype ( J:262456 )
N
• mice exhibit normal amyloid-beta production




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory