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Endonuclease-mediated Allele Detail
Symbol: Apoeem3(APOE*)Adiuj
Name: apolipoprotein E; endonuclease-mediated mutation 3, MODEL-AD Center
MGI ID: MGI:6164017
Gene: Apoe  Location: Chr7:19696109-19699188 bp, - strand  Genetic Position: Chr7, 9.94 cM
Strain of Origin:  B6(SJL)-Apoetm1.1(APOE*4)Adiuj/J
Allele Type:    Endonuclease-mediated (Humanized sequence, Inserted expressed sequence)
Mutations:    Insertion, Nucleotide substitutions
Apoeem3(APOE*)Adiuj expresses 1 gene
Mutation detailsCRISPR/Cas9 genome editing methodologies was used to introduce R130C and R176C point mutations into human APOE protein carried by the Apoetm1.1(APOE*4)Adpmc allele. (J:101977)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Apoe Mutation:  97 strains or lines available
Original:  J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
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