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Nae1tm1c(EUCOMM)Wtsi
Targeted Allele Detail
Nomenclature
Symbol: Nae1tm1c(EUCOMM)Wtsi
Name: NEDD8 activating enzyme E1 subunit 1; targeted mutation 1c, Wellcome Trust Sanger Institute
MGI ID: MGI:6159278
Gene: Nae1  Location: Chr8:104511028-104534637 bp, - strand  Genetic Position: Chr8, 53.04 cM
Mutation
origin
Mutant Cell Line:  EPD0441_1_C08
Germline Transmission:  Earliest citation of germline transmission: J:261328
Parent Cell Line:  JM8A3.N1 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Project Collection: EUCOMM
Mutation
description
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion     Vector: L1L2_Pgk_P
 
Mutation detailsFlp-mediated excision of the parental Nae1tm1a(EUCOMM)Wtsi allele resulted in the removal of the promoter-driven neomycin selection cassette and lacZ cassette leaving exon 4 floxed. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:261328)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 9 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nae1 Mutation:  24 strains or lines available
References
Original:  J:261328 Zou J, et al., Neddylation mediates ventricular chamber maturation through repression of Hippo signaling. Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):E4101-E4110
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/30/2020
MGI 6.15
The Jackson Laboratory