Sort1^tm1.2Geno
Targeted Allele Detail

Summary

• Symbol: Sort1^tm1.2Geno
• Name: sortilin 1; targeted mutation 1.2, Genoway
• MGI ID: MGI:6155013
• Synonyms: Sort1^-
• Gene: Sort1 Location: Chr3:108191398-108268827 bp, + strand Genetic Position: Chr3, 46.9 cM, cytoband F3
• Alliance: Sort1^tm1.2Geno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:234556
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 14 and a FRT-flanked neomycin selection cassette and a second loxP site were inserted downstream of exon 14. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exon 14 which encodes for part of the beta-propeller domain. Western blot analysis confirmed absence of protein in the liver of homozygotes. (J:234556)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sort1 Mutation: 47 strains or lines available

References

• Original: J:234556 Goettsch C, et al., Sortilin mediates vascular calcification via its recruitment into extracellular vesicles. J Clin Invest. 2016 Apr 1;126(4):1323-36
• All: 3 reference(s)