Piezo1tm3.1Apat
Targeted Allele Detail
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Symbol: |
Piezo1tm3.1Apat |
Name: |
piezo-type mechanosensitive ion channel component 1; targeted mutation 3.1, Ardem Patapoutian |
MGI ID: |
MGI:6154895 |
Gene: |
Piezo1 Location: Chr8:123208437-123278068 bp, - strand Genetic Position: Chr8, 71.31 cM
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Alliance: |
Piezo1tm3.1Apat page
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Germline Transmission: |
Earliest citation of germline transmission:
J:261124
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Parent Cell Line: |
Other (see notes) (ES Cell)
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Strain of Origin: |
C57BL/6N
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Allele Type: |
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Targeted (Conditional ready) |
Mutation: |
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Insertion
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Mutation details: A loxP site and FRT flanked neo cassette were inserted in intron 44, a synthetic Poly A signal, F3 flanked puro cassette and loxP site were inserted after exon 51, and a repeat of exons 45-51 with a CG7742-7743>AC (p.R2482H) mutation in exon 51 were inserted via homologous recombination. Flp-mediated recombination removed the neo and puro cassettes leaving exons 45-51 floxed and the mutated exon 51 not expressed.
(J:261124)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Piezo1 Mutation: |
87 strains or lines available
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Original: |
J:261124 Ma S, et al., Common PIEZO1 Allele in African Populations Causes RBC Dehydration and Attenuates Plasmodium Infection. Cell. 2018 Apr 5;173(2):443-455.e12 |
All: |
2 reference(s) |
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