Angptl4tm1c(EUCOMM)Hmgu
Targeted Allele Detail
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Symbol: |
Angptl4tm1c(EUCOMM)Hmgu |
Name: |
angiopoietin-like 4; targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH |
MGI ID: |
MGI:6153949 |
Synonyms: |
Angptl4fl |
Gene: |
Angptl4 Location: Chr17:33993874-34000549 bp, - strand Genetic Position: Chr17, 17.98 cM
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Alliance: |
Angptl4tm1c(EUCOMM)Hmgu page
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IMPC: |
Angptl4 gene page |
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Germline Transmission: |
Earliest citation of germline transmission:
J:260829
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Parent Cell Line: |
JM8A3.N1 (ES Cell)
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Strain of Origin: |
C57BL/6N-Atm1Brd
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Project Collection: |
EUCOMM
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Allele Type: |
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Targeted (Conditional ready) |
Mutation: |
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Insertion
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Mutation details: The L1L2_Bact_P cassette was inserted at position 33995693 of Chromosome 17 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 33997942. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele to remove the lacZ sequence and neo selection cassette, leaving loxP sites flanking the critical exon(s). Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml.
(J:260829)
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Original: |
J:260829 Singh AK, et al., Brown adipose tissue derived ANGPTL4 controls glucose and lipid metabolism and regulates thermogenesis. Mol Metab. 2018 May;11:59-69 |
All: |
4 reference(s) |
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