Ptger2^tm2.1Sna
Targeted Allele Detail

Summary

• Symbol: Ptger2^tm2.1Sna
• Name: prostaglandin E receptor 2 (subtype EP2); targeted mutation 2.1, Shuh Narumiya
• MGI ID: MGI:6149569
• Synonyms: Ptger2^flox
• Gene: Ptger2 Location: Chr14:45225652-45241277 bp, + strand Genetic Position: Chr14, 22.68 cM
• Alliance: Ptger2^tm2.1Sna page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:259019
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 1 and a loxP site and FRT flanked neo cassette were inserted downstream of exon 1 via homologous recombination. Flp mediated recombination removed the neo cassette. (J:259019)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptger2 Mutation: 32 strains or lines available

References

• Original: J:259019 Aoki T, et al., Prostaglandin E2-EP2-NF-kappaB signaling in macrophages as a potential therapeutic target for intracranial aneurysms. Sci Signal. 2017 Feb 7;10(465)
• All: 4 reference(s)