Per2^tm1.2Ual
Targeted Allele Detail

Summary

• Symbol: Per2^tm1.2Ual
• Name: period circadian clock 2; targeted mutation 1.2 Urs Albrecht
• MGI ID: MGI:6148207
• Synonyms: T Per2
• Gene: Per2 Location: Chr1:91343699-91387028 bp, - strand Genetic Position: Chr1, 46.13 cM, cytoband C5
• Alliance: Per2^tm1.2Ual page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:236282
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Cre-mediated recombination of loxP sites that flanked exon 6 resulted in the deletion of this exon. The deletion leads to a truncated PER2 protein consisting of the first 188 N-terminal amino acids (out of 1,257) plus 23 unrelated amino acids containing no structural elements involved in interaction with other clock proteins. (J:236282)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Per2 Mutation: 72 strains or lines available

References

• Original: J:236282 Chavan R, et al., Liver-derived ketone bodies are necessary for food anticipation. Nat Commun. 2016 Feb 03;7:10580
• All: 3 reference(s)