Celf1^tm1Timc
Targeted Allele Detail

Summary

• Symbol: Celf1^tm1Timc
• Name: CUGBP, Elav-like family member 1; targeted mutation 1, Nikolai A Timchenko
• MGI ID: MGI:6144284
• Synonyms: CUGBP1-S302A
• Gene: Celf1 Location: Chr2:90770727-90849842 bp, + strand Genetic Position: Chr2, 50.44 cM
• Alliance: Celf1^tm1Timc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:244612
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A substitution of AGT to GCG in exon 11 results in an alanine for serine substitution at amino acid 302 (S302A), resulting in an unphosphorylated (by cyclin D1/D2-cdk4) isoform. In addition, a neomycin resistance cassette was inserted downstream of exon 11. Translational activity of CELF1 is inhibited. (J:244612)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Celf1 Mutation: 149 strains or lines available

References

• Original: J:244612 Lewis K, et al., RNA Binding Protein CUGBP1 Inhibits Liver Cancer in a Phosphorylation-Dependent Manner. Mol Cell Biol. 2017 Aug 15;37(16)
• All: 2 reference(s)