Rr29^em1Tshir
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rr29^em1Tshir
• Name: regulatory region 29; endonuclease-mediated mutation 1, Toshihiko Shiroishi
• MGI ID: MGI:6143849
• Synonyms: deltaMFCS1
• Gene: Rr29 Location: unknown Genetic Position: Chr5, Syntenic
• Alliance: Rr29^em1Tshir page

Mutation origin

• Strain of Origin: C57BL/6JJcl

Mutation description

• Allele Type: Endonuclease-mediated (Modified regulatory region)
• Mutation: Intergenic deletion
• Rr29^em1Tshir involves 1 genes/genome features (Lmbr1) View all
• Mutation details: CRISPR-targeting removed the MFCS1 (cis regulatory element (mammals-fish-conserved-sequence 1, Mfcs1) located 1 Mb upstream of the Shh gene it regulates in intron 5 of Lmbr1). (J:257759)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr29 Mutation: 2 strains or lines available

References

• Original: J:257759 Mouri K, et al., Enhancer adoption caused by genomic insertion elicits interdigital Shh expression and syndactyly in mouse. Proc Natl Acad Sci U S A. 2018 Jan 30;115(5):1021-1026
• All: 1 reference(s)