Rims2^tm1.2Sud
Targeted Allele Detail

Summary

• Symbol: Rims2^tm1.2Sud
• Name: regulating synaptic membrane exocytosis 2; targeted mutation 1.2, Thomas C Sudhof
• MGI ID: MGI:6120885
• Synonyms: RIM2^delta
• Gene: Rims2 Location: Chr15:39061681-39547768 bp, + strand Genetic Position: Chr15, 15.45 cM, cytoband C
• Alliance: Rims2^tm1.2Sud page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:244666
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 26 was replaced with an FRT-flanked neo cassette and a floxed ECFP-tetracysteine tagged exon 26. Flp-mediated recombination removed the neo cassette. Cre-mediated recombination in the germline deleted the tagged exon 26. (J:244666)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rims2 Mutation: 250 strains or lines available

References

• Original: J:244666 Han Y, et al., RIM1 and RIM2 redundantly determine Ca2+ channel density and readily releasable pool size at a large hindbrain synapse. J Neurophysiol. 2015 Jan 01;113(1):255-63
• All: 1 reference(s)