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Islrtm1b(EUCOMM)Wtsi
Targeted Allele Detail
Nomenclature
Symbol: Islrtm1b(EUCOMM)Wtsi
Name: immunoglobulin superfamily containing leucine-rich repeat; targeted mutation 1b, Wellcome Trust Sanger Institute
MGI ID: MGI:6119548
Synonyms: Meflin-
Gene: Islr  Location: Chr9:58156246-58159236 bp, - strand  Genetic Position: Chr9, 31.63 cM
Mutation
origin
Mutant Cell Lines:  EPD0788_2_B12, EPD0788_2_H09
Germline Transmission:  Earliest citation of germline transmission: J:244530
Parent Cell Line:  JM8A3.N1 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Project Collection: EUCOMM
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion     Vector: L1L2_Bact_P
 
Mutation detailsThe L1L2_Bact_P cassette was inserted at position 58158730 of Chromosome 9 upstream of exon 2, between the two alternative exons 1 (Build GRCm38). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene cassette under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 58156661. Exon 2, which contains the entire coding region of the gene, was deleted, together with the neo cassette, through subsequent cre-mediated recombination. (J:244530)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Islr Mutation:  1 strain or line available
References
Original:  J:244530 Maeda K, et al., Identification of Meflin as a Potential Marker for Mesenchymal Stromal Cells. Sci Rep. 2016 Feb 29;6:22288
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/03/2020
MGI 6.15
The Jackson Laboratory