Phenotypes associated with this allele

• Allele Symbol: Islr^{tm1b(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:6119548
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Islr^tm1b(EUCOMM)Wtsi/Islr^tm1b(EUCOMM)Wtsi	involves: C57BL/6J * C57BL/6N	MGI:6119577

Genotype
MGI:6119577

hm1

• Allelic Composition: Islr^{tm1b(EUCOMM)Wtsi}/Islr^{tm1b(EUCOMM)Wtsi}
• Genetic Background: involves: C57BL/6J * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

skeleton phenotype ( J:244530 )

N • osteoclast number, osteoclast surface to bone surface area and thickness of tibial growth plate and proliferative zone in secondary spongiosa area of tibiae at age 10 weeks

long radius ( J:244530 )

• at age P2

long tibia ( J:244530 )

• at age P2

abnormal osteoblast morphology ( J:244530 )

• increased osteoblast surface to bone surface area in secondary spongiosa area of tibiae at age 10 weeks

increased osteoblast cell number ( J:244530 )

• in secondary spongiosa area of tibiae at age 10 weeks

abnormal osteoid morphology ( J:244530 )

• increased osteoid surface to bone surface area in secondary spongiosa area of tibiae at age 10 weeks

increased osteoid volume ( J:244530 )

• increased osteoid volume to bone volume in secondary spongiosa area of tibiae at age 10 weeks

limbs/digits/tail

long radius ( J:244530 )

• at age P2

long tibia ( J:244530 )

• at age P2

hematopoietic system

hematopoietic system phenotype ( J:244530 )

N • red blood cell, platelets, B- and T-lymphocytes and myeloid cell counts in peripheral blood

abnormal bone marrow cell morphology/development ( J:244530 )

• significant decrease in the number of clonogenic colony-forming unit fibroblasts (CFU-Fs) from isolated non-hematopoietic CD45-/Ter119- bone marrow cells from mice age P56

growth/size/body

slow postnatal weight gain ( J:244530 )

• whole body and testis at age P56

reproductive system

decreased testis weight ( J:244530 )

• at age P56

endocrine/exocrine glands

decreased testis weight ( J:244530 )

• at age P56