Adamts18^tm1.1Cbri
Targeted Allele Detail

Summary

• Symbol: Adamts18^tm1.1Cbri
• Name: ADAM metallopeptidase with thrombospondin type 1 motif 18; targeted mutation 1.1, Cathrin Brisken
• MGI ID: MGI:6118086
• Synonyms: Adamts18^KO
• Gene: Adamts18 Location: Chr8:114423758-114575370 bp, - strand Genetic Position: Chr8, 59.65 cM
• Alliance: Adamts18^tm1.1Cbri page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:237108
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-driven neomycin resistance gene flanked by FRT sites and followed by a loxP site were inserted 200 bp before exon 8 and another loxP site was inserted 200 bp after exon 9. Germline Cre-mediated recombination removed exons 8 and 9 and this is predicted to cause a frame shift resulting in a protein truncated at amino acid 405. (J:237108)

Expression

In Mice Carrying this Mutation:

3 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adamts18 Mutation: 66 strains or lines available

References

• Original: J:237108 Ataca D, et al., Adamts18 deletion results in distinct developmental defects and provides a model for congenital disorders of lens, lung, and female reproductive tract development. Biol Open. 2016 Nov 15;5(11):1585-1594
• All: 3 reference(s)