Gcgr^tm1.1Rdi
Targeted Allele Detail

Summary

• Symbol: Gcgr^tm1.1Rdi
• Name: glucagon receptor; targeted mutation 1.1, Richard DiMarchi
• MGI ID: MGI:6117294
• Synonyms: Gcgr^flox
• Gene: Gcgr Location: Chr11:120421525-120429812 bp, + strand Genetic Position: Chr11, 84.24 cM, cytoband E2
• Alliance: Gcgr^tm1.1Rdi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:238006
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 4-10 were floxed, with a neomycin resistance gene and one loxP site inserted in the intron upstream of exon 4 and the other lox P site in the intron downstream of exon 10. Flp-mediated recombination removed the neomycin cassette. (J:238006)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gcgr Mutation: 8 strains or lines available

References

• Original: J:238006 Finan B, et al., Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic Disease. Cell. 2016 Oct 20;167(3):843-857.e14
• All: 3 reference(s)