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Rimbp2tm1.2Geno
Targeted Allele Detail
Nomenclature
Symbol: Rimbp2tm1.2Geno
Name: RIMS binding protein 2; targeted mutation 1.2, Genoway
MGI ID: MGI:6116836
Gene: Rimbp2  Location: Chr5:128757791-128953486 bp, - strand  Genetic Position: Chr5, 67.91 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:238503
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA LoxP site was inserted into intron 16 and an FRT-flanked neomycin resistance cassette and a second loxP site into intron 17. The neo cassette was removed through flp-mediated recombination and exon 17 was deleted through cre-mediated recombination. Immunoblot analysis and immunostaining of hippocampal cryosections confirmed absence of protein expression from this allele. (J:238503)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rimbp2 Mutation:  34 strains or lines available
References
Original:  J:238503 Grauel MK, et al., RIM-binding protein 2 regulates release probability by fine-tuning calcium channel localization at murine hippocampal synapses. Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):11615-11620
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/07/2020
MGI 6.14
The Jackson Laboratory