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Arid1bem1Hzhu
Endonuclease-mediated Allele Detail
Nomenclature
Symbol: Arid1bem1Hzhu
Name: AT rich interactive domain 1B (SWI-like); endonuclease mediated mutation 1, Hao Zhu
MGI ID: MGI:6116819
Synonyms: Arid1bdelta
Gene: Arid1b  Location: Chr17:4994332-5347656 bp, + strand  Genetic Position: Chr17, 2.83 cM
Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsExon 5 was deleted using CRISPR/Cas9 mutagenesis. qPCR analysis revealed that mRNA transcripts were reduced in the liver, whole brain, pituitary gland, dentate gyrus, and hypothalamus of heterozygous mutant mice. Western blot analysis confirmed the reduction of protein levels in heterozygous P0 limbs and P45 whole brain extracts, and the absence of protein in homozygous P0 mutant pups. (J:256668)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 11 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Arid1b Mutation:  25 strains or lines available
References
Original:  J:256668 Celen C, et al., Arid1b haploinsufficient mice reveal neuropsychiatric phenotypes and reversible causes of growth impairment. Elife. 2017 Jul 11;6
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory