Arid1b^em1Hzhu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Arid1b^em1Hzhu
• Name: AT-rich interaction domain 1B; endonuclease-mediated mutation 1, Hao Zhu
• MGI ID: MGI:6116819
• Synonyms: Arid1b^delta
• Gene: Arid1b Location: Chr17:5044607-5397931 bp, + strand Genetic Position: Chr17, 2.83 cM
• Alliance: Arid1b^em1Hzhu page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 5 was deleted using CRISPR/Cas9 mutagenesis. qPCR analysis revealed that mRNA transcripts were reduced in the liver, whole brain, pituitary gland, dentate gyrus, and hypothalamus of heterozygous mutant mice. Western blot analysis confirmed the reduction of protein levels in heterozygous P0 limbs and P45 whole brain extracts, and the absence of protein in homozygous P0 mutant pups. (J:256668)

Disease models

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Arid1b Mutation: 110 strains or lines available

References

• Original: J:256668 Celen C, et al., Arid1b haploinsufficient mice reveal neuropsychiatric phenotypes and reversible causes of growth impairment. Elife. 2017 Jul 11;6:e25730
• All: 1 reference(s)