Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arid1bem1Hzhu mutation
(0 available);
any
Arid1b mutation
(110 available)
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mortality/aging
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• homozygotes are born but die perinatally
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growth/size/body
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• P0 homozygotes are significantly smaller than wild-type controls
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arid1bem1Hzhu mutation
(0 available);
any
Arid1b mutation
(110 available)
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growth/size/body
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• heterozygotes survive into adulthood and appear healthy but are small for age
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• heterozygotes show decreased body weight with no apparent changes in food intake or water consumption
• after 40 days of treatment with recombinant mouse GH (rmGH), heterozygotes gain significantly more body weight than wild-type controls
• treatment with recombinant human IGF1 (rhIGF1) failed to rescue the body weight abnormality
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• heterozygotes show reduced nose-to-rump length relative to wild-type controls
• after 40 days of treatment with recombinant mouse GH (rmGH), heterozygotes gain significantly more nose-to-rump length than wild-type controls
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• growth retardation is reversed by exogenous GH supplementation
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behavior/neurological
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• heterozygotes show no significant deficits in locomotor activity, memory and learning, or foot shock sensitivity relative to wild-type controls
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• in the open field test, heterozygotes spend significantly more time in the periphery, avoiding the anxiety-provoking center
• in the elevated plus maze, heterozygotes spend more time in the anxiety-relieving, walled arms of the maze
• in the dark-light box test, male heterozygotes avoid exploring the brightly lit chamber
• treatment with either recombinant human IGF1 (rhIGF1) or recombinant mouse GH (rmGH) failed to rescue the anxiety behavioral phenotype, as measured in the elevated plus maze
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• heterozygotes spend significantly less time interacting with unfamiliar juvenile mice
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• heterozygotes show increased self-grooming behavior and, potentially as a result, bury less marbles than wild-type controls in the marble-burying test
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• at baseline, both fore- and hindlimb grip strength is lower than that in wild-type controls
• after 40 days of treatment with rmGH, heterozygotes gain significantly more grip strength than wild-type controls
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• during separation of pups from dams at P4, ultrasonic vocalizations (USVs ) are longer in duration and have an abnormal pitch
• however, total number of USVs emitted is normal relative to wild-type controls
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nervous system
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• 6.6% of heterozygotes exhibit hydrocephalus
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• at P50, corpus callosum volume is significantly reduced
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• a reduction in proliferating cells is observed in the subgranular zone of the dentate gyrus, esp. in posterior regions
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• at P50, dentate gyrus volume is significantly reduced
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• decreased cortex thickness is accompanied by reduced TBR1+ neuronal cellularity (TBR1 is an early neuronal marker)
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• heterozygous pups show decreased cortex thickness with reduced TBR1+ neuronal cellularity
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• reduced cortical thickness is accompanied by reduced neuron numbers
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• in the mediobasal hypothalamus, Ghrh mRNA levels are similar to those in wild-type controls, indicating a lack of appropriate GHRH response to the observed IGF1 deficiency
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homeostasis/metabolism
muscle
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• at P50, heterozygous exhibit muscle weakness, as shown by grip strength testing
• muscle strength is significantly improved by exogenous GH supplementation
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cardiovascular system
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• hearts are disproportionally small
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• heart/body weight ratio is significantly lower than that in wild-type controls
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renal/urinary system
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• kidneys are disproportionally small
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• kidney/body weight ratio is significantly lower than that in wild-type controls
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