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Targeted Allele Detail
Symbol: Hltftm1.1Hdin
Name: helicase-like transcription factor; targeted mutation 1.1, Hao Ding
MGI ID: MGI:6108112
Gene: Hltf  Location: Chr3:20057811-20118490 bp, + strand  Genetic Position: Chr3, 6.15 cM
Germline Transmission:  Earliest citation of germline transmission: J:252991
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe genomic sequence for the coding part of exon 1 plus exons 2-5 (coding for amino-acids 2-208) was replaced with a lacZ reporter gene cassette and a loxP site flanked neomycin resistance gene cassette. The neo cassette was removed through subsequent Cre-mediated recombination, leaving a combined reporter null allele. Northern blot and RT-PCR analysis confirmed the absence of endogenous transcripts from this allele. (J:252991)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 43 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hltf Mutation:  0 strains or lines available
Original:  J:252991 Sandhu S, et al., Loss of HLTF function promotes intestinal carcinogenesis. Mol Cancer. 2012 Mar 27;11:18
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.15
The Jackson Laboratory