Mettl14^tm1.1Chhe
Targeted Allele Detail

Summary

• Symbol: Mettl14^tm1.1Chhe
• Name: methyltransferase 14, N6-adenosine-methyltransferase subunit; targeted mutation 1.1, Chuan He
• MGI ID: MGI:6101495
• Synonyms: Mettl14^f, Mettl14^floxed
• Gene: Mettl14 Location: Chr3:123161944-123179639 bp, - strand Genetic Position: Chr3, 53.96 cM
• Alliance: Mettl14^tm1.1Chhe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:247703
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Exons 7, 8, and 9 of the gen were targeted by inserting a single loxP site in intron 6 and an FRT-flanked neomycin resistance gene coupled with a loxP site in intron 9. The loxP sites flank the sequences encoding the DPWW active motif. The FRT-flanked neomycin selection cassette was removed via FLP-mediated recombination. (J:247703)

Expression

In Mice Carrying this Mutation:

5 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mettl14 Mutation: 37 strains or lines available

References

• Original: J:247703 Yoon KJ, et al., Temporal Control of Mammalian Cortical Neurogenesis by m6A Methylation. Cell. 2017 Nov 02;171(4):877-889.e17
• All: 13 reference(s)