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Targeted Allele Detail
Symbol: Fustm1.1Emcf
Name: fused in sarcoma; targeted mutation 1.1, Elizabeth MC Fisher
MGI ID: MGI:6100933
Synonyms: FUS Delta14, Fustm1Emcf
Gene: Fus  Location: Chr7:127565276-127581204 bp, + strand  Genetic Position: Chr7, 69.87 cM
Germline Transmission:  Earliest citation of germline transmission: J:249965
Parent Cell Line:  JM8.F6 (ES Cell)
Strain of Origin:  C57BL/6N
Allele Type:    Targeted (Humanized sequence)
Mutations:    Insertion, Nucleotide substitutions
Mutation detailsAn A to G splice mutation was introduced betweeen exon 13 and 14 along with humanization of the coding sequence of exon 15 through the following sequence changes: g.14230 C to T, g.14232 A to T, g.14234 C to G, g.14260 A to G, and g.14266 ATTA insertion. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette. (J:249965)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fus Mutation:  16 strains or lines available
Original:  J:249965 Devoy A, et al., Humanized mutant FUS drives progressive motor neuron degeneration without aggregation in 'FUSDelta14' knockin mice. Brain. 2017 Nov 1;140(11):2797-2805
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory