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Fustm1.1Emcf
Targeted Allele Detail
Nomenclature
Symbol: Fustm1.1Emcf
Name: fused in sarcoma; targeted mutation 1.1, Elizabeth MC Fisher
MGI ID: MGI:6100933
Synonyms: FUS Delta14, Fustm1Emcf
Gene: Fus  Location: Chr7:127966789-127982032 bp, + strand  Genetic Position: Chr7, 69.87 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:249965
Parent Cell Line:  JM8.F6 (ES Cell)
Strain of Origin:  C57BL/6N
Mutation
description
Allele Type:    Targeted (Humanized sequence)
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsAn A to G splice mutation was introduced betweeen exon 13 and 14 along with humanization of the coding sequence of exon 15 through the following sequence changes: g.14230 C to T, g.14232 A to T, g.14234 C to G, g.14260 A to G, and g.14266 ATTA insertion. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette. (J:249965)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fus Mutation:  15 strains or lines available
References
Original:  J:249965 Devoy A, et al., Humanized mutant FUS drives progressive motor neuron degeneration without aggregation in 'FUSDelta14' knockin mice. Brain. 2017 Nov 1;140(11):2797-2805
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
07/29/2020
MGI 6.15
The Jackson Laboratory