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Tifabtm1.1Dsta
Targeted Allele Detail
Nomenclature
Symbol: Tifabtm1.1Dsta
Name: TRAF-interacting protein with forkhead-associated domain, family member B; targeted mutation 1.1, Daniel T Starczynowski
MGI ID: MGI:5911664
Gene: Tifab  Location: Chr13:56173704-56178885 bp, - strand  Genetic Position: Chr13, 30.06 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:229024
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 3 which encodes the protein coding region was replaced with a beta- galactosidase cassette and a floxed neo cassette via homologous recombination. Cre mediated recombination removed the neo cassette. Immunoblot analysis confirmed the absence of protein expression in bone marrow lysates from homozygous mice. (J:229024)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tifab Mutation:  13 strains or lines available
References
Original:  J:229024 Varney ME, et al., Loss of Tifab, a del(5q) MDS gene, alters hematopoiesis through derepression of Toll-like receptor-TRAF6 signaling. J Exp Med. 2015 Oct 19;212(11):1967-85
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/30/2020
MGI 6.15
The Jackson Laboratory