Fcgr3^tm2.1Jsv
Targeted Allele Detail

Summary

• Symbol: Fcgr3^tm2.1Jsv
• Name: Fc receptor, IgG, low affinity III; targeted mutation 2.1, J Sjef Verbeek
• MGI ID: MGI:5909292
• Synonyms: Floxed FcgammaRIII
• Gene: Fcgr3 Location: Chr1:170878743-170892504 bp, - strand Genetic Position: Chr1, 78.8 cM
• Alliance: Fcgr3^tm2.1Jsv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:264675
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: This allele was derived from Fcgr3^tm2Sjv by flpe recombinase excision of a FRT-flanked hygromycin resistance cassette, leaving a loxP site followed by a single FRT site upstream and a second loxP site downstream of exon 4, which encodes extracellular domain 2 (EC2) of the protein. (J:264675)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fcgr3 Mutation: 29 strains or lines available

References

• Original: J:264675 Fransen MF, et al., A Restricted Role for FcgammaR in the Regulation of Adaptive Immunity. J Immunol. 2018 Apr 15;200(8):2615-2626
• All: 1 reference(s)