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Endonuclease-mediated Allele Detail
Symbol: Apoeem2(APOE*)Adiuj
Name: apolipoprotein E; endonuclease-mediated mutation 1, MODEL-AD Center
MGI ID: MGI:5907023
Synonyms: APOEepsilon3
Gene: Apoe  Location: Chr7:19696109-19699188 bp, - strand  Genetic Position: Chr7, 9.94 cM
Strain of Origin:  B6(SJL)-Apoetm1.1(APOE*4)Adiuj/J
Allele Type:    Endonuclease-mediated (Humanized sequence, Inserted expressed sequence)
Mutations:    Insertion, Nucleotide substitutions
Apoeem2(APOE*)Adiuj expresses 1 gene
Mutation detailsCRISPR-Cas9 methodology introduced a R130C point mutation into the human APOE protein carried by the Apoetm1.1(APOE*4)Adpmc allele. (J:300626)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Apoe Mutation:  128 strains or lines available
Original:  J:300626 Foley KE, et al., APOE and APOE genotypes drive unique gene signatures in the cortex of young mice. bioRxiv. 2020;
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory