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Apoeem2(APOE*)Adiuj
Endonuclease-mediated Allele Detail
Nomenclature
Symbol: Apoeem2(APOE*)Adiuj
Name: apolipoprotein E; endonuclease-mediated mutation 1, MODEL-AD Center
MGI ID: MGI:5907023
Gene: Apoe  Location: Chr7:19696109-19699188 bp, - strand  Genetic Position: Chr7, 9.94 cM
Mutation
origin
Strain of Origin:  B6(SJL)-Apoetm1.1(APOE*4)Adiuj/J
Mutation
description
Allele Type:    Endonuclease-mediated (Humanized sequence, Inserted expressed sequence)
Mutations:    Insertion, Nucleotide substitutions
 
Apoeem2(APOE*)Adiuj expresses 1 gene
 
Mutation detailsCRISPR-Cas9 methodology introduced a R130C point mutation into the human APOE protein carried by the Apoetm1.1(APOE*4)Adpmc allele. (J:101977)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Apoe Mutation:  97 strains or lines available
References
Original:  J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/14/2020
MGI 6.14
The Jackson Laboratory