Chaer1^em1Holi
Endonuclease-mediated Allele Detail

Summary

• Symbol: Chaer1^em1Holi
• Name: cardiac hypertrophy associated epigenetic regulator 1; endonuclease-mediated mutation 1, Hongliang Li
• MGI ID: MGI:5905817
• Synonyms: Chaer1-KO
• Gene: Chaer1 Location: Chr5:77283791-77288173 bp, - strand Genetic Position: Chr5, Syntenic
• Alliance: Chaer1^em1Holi page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This knockout allele was created by deleting exon 2 (which represents the bulk of the gene) using CRISPR/Cas9 technology. The sgRNAs flanking the exon were 5'-GTAGTTTGCACGTTAGCAAG-3' upstream and 5'-GATTACCGAGAACTGCCCGA-3' downstream. (J:240516)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chaer1 Mutation: 0 strains or lines available

References

• Original: J:240516 Wang Z, et al., The long noncoding RNA Chaer defines an epigenetic checkpoint in cardiac hypertrophy. Nat Med. 2016 Oct;22(10):1131-1139
• All: 1 reference(s)