Atp2b1^tm1.1Raku
Targeted Allele Detail

Summary

• Symbol: Atp2b1^tm1.1Raku
• Name: ATPase, Ca++ transporting, plasma membrane 1; targeted mutation 1.1, Rajiv Kumar
• MGI ID: MGI:5888894
• Synonyms: Pmca1^fl
• Gene: Atp2b1 Location: Chr10:98750268-98862005 bp, + strand Genetic Position: Chr10, 50.97 cM, cytoband C3
• Alliance: Atp2b1^tm1.1Raku page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:232942
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 2. An additional loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the selection cassette and left exon 2 floxed. (J:232942)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Atp2b1 Mutation: 65 strains or lines available

References

• Original: J:232942 Ryan ZC, et al., Deletion of the intestinal plasma membrane calcium pump, isoform 1, Atp2b1, in mice is associated with decreased bone mineral density and impaired responsiveness to 1, 25-dihydroxyvitamin D3. Biochem Biophys Res Commun. 2015 Nov 6;467(1):152-6
• All: 1 reference(s)