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Atp2b1tm1.1Raku
Targeted Allele Detail
Nomenclature
Symbol: Atp2b1tm1.1Raku
Name: ATPase, Ca++ transporting, plasma membrane 1; targeted mutation 1.1, Rajiv Kumar
MGI ID: MGI:5888894
Synonyms: Pmca1fl
Gene: Atp2b1  Location: Chr10:98914630-99026143 bp, + strand  Genetic Position: Chr10, 50.97 cM, cytoband C3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:232942
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsAn FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 2. An additional loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the selection cassette and left exon 2 floxed. (J:232942)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Atp2b1 Mutation:  15 strains or lines available
References
Original:  J:232942 Ryan ZC, et al., Deletion of the intestinal plasma membrane calcium pump, isoform 1, Atp2b1, in mice is associated with decreased bone mineral density and impaired responsiveness to 1, 25-dihydroxyvitamin D3. Biochem Biophys Res Commun. 2015 Nov 6;467(1):152-6
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory