Smyd3tm1d(KOMP)Wtsi
Targeted Allele Detail
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Symbol: |
Smyd3tm1d(KOMP)Wtsi |
Name: |
SET and MYND domain containing 3; targeted mutation 1d, Wellcome Trust Sanger Institute |
MGI ID: |
MGI:5883836 |
Synonyms: |
Smyd3- |
Gene: |
Smyd3 Location: Chr1:178779525-179345606 bp, - strand Genetic Position: Chr1, 83.48 cM, cytoband H3
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Alliance: |
Smyd3tm1d(KOMP)Wtsi page
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IMPC: |
Smyd3 gene page |
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Germline Transmission: |
Earliest citation of germline transmission:
J:240508
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Parent Cell Line: |
JM8.N4 (ES Cell)
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Strain of Origin: |
C57BL/6N
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Project Collection: |
KOMP-CSD
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Allele Type: |
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Targeted (Null/knockout) |
Mutation: |
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Intragenic deletion
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Mutation details: The L1L2_gt2 cassette was inserted at position 179250641 of Chromosome 1 upstream of the critical exon 2 (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of exon 2 at position 179251462. The critical exon(s) is/are thus flanked by loxP sites. A null/knockout allele was created by flp and cre recombinase expression in mice carrying this allele to remove the lacZ sequence, neo selection cassette and the loxP-flanked exon 2.
(J:240508)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Smyd3 Mutation: |
40 strains or lines available
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Original: |
J:240508 Bagislar S, et al., Smyd2 is a Myc-regulated gene critical for MLL-AF9 induced leukemogenesis. Oncotarget. 2016 Oct 11;7(41):66398-66415 |
All: |
1 reference(s) |
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