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Smyd3tm1d(KOMP)Wtsi
Targeted Allele Detail
Summary
Symbol: Smyd3tm1d(KOMP)Wtsi
Name: SET and MYND domain containing 3; targeted mutation 1d, Wellcome Trust Sanger Institute
MGI ID: MGI:5883836
Synonyms: Smyd3-
Gene: Smyd3  Location: Chr1:178779525-179345606 bp, - strand  Genetic Position: Chr1, 83.48 cM, cytoband H3
Alliance: Smyd3tm1d(KOMP)Wtsi page
IMPC: Smyd3 gene page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:240508
Parent Cell Line:  JM8.N4 (ES Cell)
Strain of Origin:  C57BL/6N
Project Collection: KOMP-CSD
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThe L1L2_gt2 cassette was inserted at position 179250641 of Chromosome 1 upstream of the critical exon 2 (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of exon 2 at position 179251462. The critical exon(s) is/are thus flanked by loxP sites. A null/knockout allele was created by flp and cre recombinase expression in mice carrying this allele to remove the lacZ sequence, neo selection cassette and the loxP-flanked exon 2. (J:240508)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Smyd3 Mutation:  40 strains or lines available
References
Original:  J:240508 Bagislar S, et al., Smyd2 is a Myc-regulated gene critical for MLL-AF9 induced leukemogenesis. Oncotarget. 2016 Oct 11;7(41):66398-66415
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/28/2024
MGI 6.13
The Jackson Laboratory