Smyd3tm1c(KOMP)Wtsi
Targeted Allele Detail
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Symbol: |
Smyd3tm1c(KOMP)Wtsi |
Name: |
SET and MYND domain containing 3; targeted mutation 1c, Wellcome Trust Sanger Institute |
MGI ID: |
MGI:5883835 |
Synonyms: |
Smyd3flox |
Gene: |
Smyd3 Location: Chr1:178779525-179345606 bp, - strand Genetic Position: Chr1, 83.48 cM, cytoband H3
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Alliance: |
Smyd3tm1c(KOMP)Wtsi page
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IMPC: |
Smyd3 gene page |
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Germline Transmission: |
Earliest citation of germline transmission:
J:240508
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Parent Cell Line: |
JM8.N4 (ES Cell)
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Strain of Origin: |
C57BL/6N
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Project Collection: |
KOMP-CSD
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Allele Type: |
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Targeted (Conditional ready) |
Mutation: |
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Insertion
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Mutation details: The L1L2_gt2 cassette was inserted at position 179250641 of Chromosome 1 upstream of the critical exon 2 (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of exon 2 at position 179251462. The critical exon 2 is thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele to remove the lacZ sequence and neo selection cassette, leaving loxP sites flanking exon 2.
(J:240508)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Smyd3 Mutation: |
40 strains or lines available
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Original: |
J:240508 Bagislar S, et al., Smyd2 is a Myc-regulated gene critical for MLL-AF9 induced leukemogenesis. Oncotarget. 2016 Oct 11;7(41):66398-66415 |
All: |
3 reference(s) |
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