Dpysl2^tm1Zhxu
Targeted Allele Detail

Summary

• Symbol: Dpysl2^tm1Zhxu
• Name: dihydropyrimidinase-like 2; targeted mutation 1, Zhiheng Xu
• MGI ID: MGI:5882589
• Synonyms: Crmp2 cKO
• Gene: Dpysl2 Location: Chr14:67040313-67106137 bp, - strand Genetic Position: Chr14, 34.6 cM
• Alliance: Dpysl2^tm1Zhxu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:239909
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6 x 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into intron 2 and an FRT site flanked neomycin resistance gene cassette and a second loxP site were inserted into intron 3, creating a conditional-ready allele with a floxed exon 3. (J:239909)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dpysl2 Mutation: 34 strains or lines available

References

• Original: J:239909 Zhang H, et al., Brain-specific Crmp2 deletion leads to neuronal development deficits and behavioural impairments in mice. Nat Commun. 2016 Jun 01;7
• All: 2 reference(s)