F2rl1^tm1.1Wmrf
Targeted Allele Detail

Summary

• Symbol: F2rl1^tm1.1Wmrf
• Name: F2R like trypsin receptor 1; targeted mutation 1.1, Wolfram Ruf
• MGI ID: MGI:5828555
• Synonyms: PAR2^INS, R38E-PAR2
• Gene: F2rl1 Location: Chr13:95648240-95661735 bp, - strand Genetic Position: Chr13, 49.53 cM
• Alliance: F2rl1^tm1.1Wmrf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:230080
• Parent Cell Line: C2 (Nagy) (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Nucleotide substitutions
• Mutation details: Arginine codon 38 (AGA) in exon 2 was changed to glutamic acid (GAG) (p.R38E). Exon 2 was flanked by loxP sites. The FRT site flanked selection cassette that was inserted was removed through subsequent Flp-mediated recombination. The mutation renders the encoded peptide cleavage-resistant. (J:230080)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any F2rl1 Mutation: 60 strains or lines available

References

• Original: J:222109 Liang HP, et al., EPCR-dependent PAR2 activation by the blood coagulation initiation complex regulates LPS-triggered interferon responses in mice. Blood. 2015 Apr 30;125(18):2845-54
• All: 7 reference(s)