Prdx6tm3.1Abf
Targeted Allele Detail
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Symbol: |
Prdx6tm3.1Abf |
Name: |
peroxiredoxin 6; targeted mutation 3.1, Aron B Fisher |
MGI ID: |
MGI:5825152 |
Synonyms: |
C47S |
Gene: |
Prdx6 Location: Chr1:161067682-161078780 bp, - strand Genetic Position: Chr1, 69.75 cM
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Alliance: |
Prdx6tm3.1Abf page
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Germline Transmission: |
Earliest citation of germline transmission:
J:239138
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Parent Cell Line: |
EAP6 (ES Cell)
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Strain of Origin: |
C57BL/6
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Allele Type: |
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Targeted (Not Applicable) |
Mutation: |
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Single point mutation
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Mutation details: The targeting vector is designed to insert, by site-directed mutagenesis, a TGC to TCC point mutation followed by a FRT-flanked neomycin cassette in exon 2. The mutation results in an alteration of the corresponding amino acid from cysteine to serine (C47S) at codon 47. Flp-mediated recombination removed the FRT-flanked neo cassette. The mutation does not affect phospholipase A2 activity, but does eliminate peroxidase activity.
(J:239138)
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Original: |
J:239138 Li H, et al., Critical role of peroxiredoxin 6 in the repair of peroxidized cell membranes following oxidative stress. Free Radic Biol Med. 2015 Oct;87:356-65 |
All: |
3 reference(s) |
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